GRUPO DE CÉLULAS MADRE Y TERAPIA CELULAR
ÁREA TERAPIAS AVANZADAS
Coordinador del grupo
Investigadores Colaboradores Externos
Líneas de Investigación
- Células madre y terapia celular.
- Terapias avanzadas en biomedicina.
- Papel de las células madre mesenquimales y neurorregeneración.
- Caracterización de células madre mesenquimales de placenta para su empleo en terapias avanzadas.
- Estudio de los mecanismos de la regeneración neuronal del SNC adulto.
- Terapias Avanzadas para la reparación cardiaca tras un infarto agudo de miocardio mediante el uso de células madre mesenquimales derivadas de la placenta humana y nanotecnología.
- Estudio del papel de una nueva isoforma de tau producida por retención intrónica y su papel en procesos neurodegenerativos.
- Prevención y tratamiento de patologías cardiovasculares.
Papers Recientes
- de Laorden EH, Simón D, Milla S, Portela-Lomba M, Mellén M, Sierra J, de la Villa P, Moreno-Flores MT, Iglesias M. Human placenta-derived mesenchymal stem cells stimulate neuronal regeneration by promoting axon growth and restoring neuronal activity. Front Cell Dev Biol. 11:1328261. 2024;
- Portela-Lomba M, Simón D, Callejo-Móstoles, M, De la Fuente G, Fernández de Sevilla D, García-Escudero M, Moreno-Flores MT, Sierra J. Generation of functional neurons from adult human mucosal olfactory ensheathing glia by direct lineage conversión. Cell Death and Disease 15, 478 (2024) doi:10.1038/s41419-024-06862-9
- Domene Serrano I, Cuadros R, Hernandez F, Avila J, Santa María I. Tridimensional Structural Analysis of Tau Isoforms Generated by Intronic Retention. Journal of Alzheimer’s Disease Reports. 7 – 1, pp. 1259 – 1265.
- Kim YA, Siddiqui T, Blaze J, Cosacak MI, Winters T, Kumar A, Tein E, Sproul AA, Teich AF, Bartolini F, Akbarian S, Kizil C, Hargus G, Santa-Maria I. RNA methyltransferase NSun2 deficiency promotes neurodegeneration through epitranscriptomic regulation of tau phosphorylation. Acta Neuropathologica. 145(1):29-48 (2023)
- Asadzadeh J, Ruchti E, Jiao W, Limoni G, MacLachlan C, Small SA, Knott G, Santa-Maria I, McCabe BD. Retromer deficiency in Tauopathy models enhances the truncation and toxicity of Tau. Nature Communications. 13(1):5049 (2023)
- Siddiqui T, Cosacak MI, Popova S, Bhattarai P, Yilmaz E, Lee AJ, Min Y, Wang X, Allen M, İş Ö, Atasavum ZT, Rodriguez-Muela N, Vardarajan BN, Flaherty D, Teich AF, Santa-Maria I, Freudenberg U, Werner C, Tosto G, Mayeux R, Ertekin-Taner N, Kizil C. Nerve growth factor receptor (Ngfr) induces neurogenic plasticity by suppressing reactive astroglial Lcn2/Slc22a17 signaling in Alzheimer’s disease. NPJ Regenerative Medicine. 8(1):33 (2023)
- MA Garcia, Raúl Gago, M Arroyo-Hernández, EH De Laorden, M Iglesias, D Esteban-Mendoza, R Cuerno, J. Texturization of polycrystalline titanium surfaces after low-energy ion-beam irradiation: Impact on biocompatibility. Surface and Coatings Technology, 458;129363. 2023
- Aljama S, Lago EP, Zafra O, Sierra J, Simón D, Santos C, Pascual JR, Garcia-Romero N. Dichotomous colorectal cancer behaviour. Crit Rev Oncol Hematol. 2023 Sep;189:104067. doi: 10.1016/j.critrevonc.2023.104067. Epub 2023 Jul 15.
- Portela-Lomba M, Simón D, Fernández de Sevilla D, Moreno-Flores MT, Sierra J. Small molecules fail to induce direct reprogramming of adult rat olfactory ensheathing glia to mature neurons. Front Mol Neurosci. 2023 Feb 24;16:1110356. doi: 10.3389/fnmol.2023.1110356.
- M.A. Garcia, R. Gago, M. Arroyo-Hernández, E.H. de Laorden, M. Iglesias, D. Esteban-Mendoza, R. Cuerno, J. Rickards. Texturization of polycrystalline titanium surfaces after low-energy ion-beam irradiation: Impact on biocompatibility, Surface and Coatings Technology, Volume 458, 2023, 129363, ISSN 0257-8972. https://doi.org/10.1016/j.surfcoat.2023.129363
- Matteo Bordi; Sandipkumar Darji; Yutaka Sato; Marian Mellén; Martin Berg; Asok Kumar; Ying Jiang; Ralph Nixon. mTOR hyperactivation in Down Syndrome underlies deficits in autophagy induction, autophagosome formation, and mitophagy. Cell Death & Disease. 10 – 563, Springer Nature, 10/07/2019.
- Ignacio Hernandez-Navarro; Laura Botana; Javier Díez-Mata; et al. Replicative Endothelial Cell Senescence May Lead to Endothelial Dysfunction by Increasing the BH2/BH4 Ratio Induced by Oxidative Stress, Reducing BH4 Availability, and Decreasing the Expression of eNOS. International Journal of Molecular Science. MDPI. 25-18. https://doi.org/10.3390/ijms25189890.