MOLECULAR ONCOLOGY GROUP
ADVANCED THERAPIES AREA
Principal Investigator
Postgraduate Students
- Maria Ferrer Aporta (UFV, Biomedicine)
- Daniela D’Empaire (UFV, Biotechnology) AECC Fellowship
Research Assistant
- Alba Lopez de Uralde Grande (PEJ, Community of Madrid)
End-of-Degree/End-of-Master’s-Degree Students
- Clara Rodriguez Blanco (End-of-Degree, UCM)
- Guillem Arbiol Lopez de Zamora (Master’s Degree in Bioinformatics, UAM)
- Luis Miguel Viborras Caballero (Master’s Degree in Bioinformatics, ISCIII)
- Sandra Cordero (Master’s Degree in Bioinformatics, UFV)
- Carlos Celaya (UFV, Biomedical Engineering)
- Irene Lloret Pacheco (UFV, Biomedicine)
- Ignacio Diaz Rodríguez (UAH, Health Biology)
Research Summary
Among our main lines of research, we focus on deciphering the fundamental processes that drive the development and progression of pancreatic cancer, with the purpose of identifying vulnerabilities that can be exploited to develop new therapeutic strategies.
In this context, we approach this disease in a comprehensive manner, analyzing both the specific processes of the tumor cell and its interaction with the micro environment. Our aim is to identify new therapeutic targets that allow us to intervene more effectively in these key mechanisms. To this end, we use an integrative approach that combines experimental and computational tools.
At the experimental level, we employ advanced technologies based on omics techniques and preclinical models to investigate the molecular mechanisms that drive tumor progression. In parallel, we perform multiple types of bioinformatics analyses and develop computational predictive models to identify biomarkers and targets with clinical potential.
This multidisciplinary approach allows us to efficiently generate and validate hypotheses by integrating data obtained in the laboratory with in silico analyses. This broadens our understanding of pancreatic cancer and facilitates the development of innovative and personalized therapeutic strategies.
Projects awarded
- Chromatin remodelers as therapeutic immuno-modulators in pancreatic ductal adenocarcinoma. Health Research Fund (FIS). Principal Investigator. FIS PI22/00492 Duration until January 2025
- BPTF and chromatin remodelers as new therapeutic targets in pancreatic carcinoma. Health Research Fund (FIS). Principal Investigator. PI18/01080. Duration: January 2019-December 2022.
- BPTF as a therapeutic target and regulator of cell plasticity in pancreatic ductal adenocarcinoma. ASEICA +QUEUNTRAIL. Principal Investigator. Duration January 2020-December 2020
Publications
- Ana García García, María Ferrer Aporta, Germán Vallejo Palma, Antonio Giráldez Trujillo, Raquel Castillo-González, David Calzón Lozano, Alberto Mora Perdiguero, Raúl Muñoz Velasco, Miguel Colina Castro, Elena de Simone Benito, Raul TorresRuiz, Sandra Rodriguez-Perales, Jonas Dehairs, Johannes V Swinnen, Juan Carlos Garcia-Cañaveras, Agustín Lahoz, Sandra Montalvo Quirós, Carlos del PozoRojas, Clara Luque Rioja, Francisco Monroy, Diego Herráez-Aguilar, Marina Alonso Riaño, José Luis Rodríguez Peralto, Víctor Javier Sánchez-Arévalo Lobo* ELOVL6 as a Therapeutic Target: Disrupting c-MYC-Driven Lipid Metabolism to Enhance Chemotherapy in Pancreatic Cancer . Nature Communications. (2025)
- González, Paula Pena, Dafne Lozano-Paredes, José Luis Rojo-Álvarez, Luis Bote-Curiel, y Víctor Javier Sánchez-Arévalo Lobo. «Pymportx: Facilitating next-Generation Transcriptomics Analysis in Python». NAR Genomics and Bioinformatics 6, 4 (2024): lqae160. https://doi.org/10.1093/nargab/lqae160.
- López-Gil, Juan Carlos, Susana García-Silva, Laura Ruiz-Cañas, Diego Navarro, Adrián Palencia-Campos, Antonio Giráldez-Trujillo, Julie Earl, et al. 2024. The Peptidoglycan Recognition Protein 1 Confers Immune Evasive Properties on Pancreatic Cancer Stem Cells. Gut, gutjnl-2023-330995. https://doi.org/10.1136/gutjnl-2023-330995.
- Blanco-García, Leyla, Yolanda Ruano, Raquel Blanco Martínez-Illescas, Rocío Cubo, Paula Jiménez Sánchez, Sanchez-Arevalo Lobo, V.J., Erica Riveiro Falkenbach, Pablo Ortiz Romero, María C. Garrido, and José L. Rodríguez Peralto. 2023. pTERT C250T Mutation: A Potential Biomarker of Poor Prognosis in Metastatic Melanoma. Heliyon 9 (8): e18953. (2023). https://doi.org/10.1016/j.heliyon.2023.e18953. PMCID: PMC10440525
- Arconada-Luque, Elena Jiménez-Suarez, Jaime Pascual-Serra, Raquel Nam-Cha, Syong Hyun Moline, Teresa Cimas, Francisco J. Fliquete, Germán Ortega-Muelas, Marta Roche, Olga Fernández-Aroca, Diego M.Velasco, Raúl Muñoz García-Flores, Natalia Garnés-García, Cristina Sánchez-Fdez, Adrián Matilla-Almazán, Sofía, Sanchez-Arevalo Lobo, V.J. Hernández-Losa, Javier Belandia, Borja Pandiella, Atanasio Esparís-Ogando, Azucena Cajal, Santiago Ramón y Cajal, Peso, Luis del Sánchez-Prieto, Ricardo Ruiz-Hidalgo, María José. ERK5 Is a Major Determinant of Chemical Sarcomagenesis: Implications in Human Pathology. Cancers 14, 3509 (2022). https://doi.org/10.3390/cancers14143509. PMCID: PMC9316148. Q1
- Velasco, R. M.; Sánchez, P. J.; García, A. G.; Martinez-Illescas, R. B.; Senovilla, Á. P.; Yagüe, M. L.; Trento, A.; García-Martin, R. M.; Navarro, D.; Sainz, B.; Peralto, J. L. R.; Sánchez-Arévalo Lobo, V.J. Targeting BPTF Sensitizes Pancreatic Ductal Adenocarcinoma to Chemotherapy by Repressing ABC-Transporters and Impairing Multidrug Resistance (MDR). Cancers 2022, 14 (6), 1518. https://doi.org/10.3390/cancers14061518. PMID: 35326669
- Velasco, R. M., García, A. G., Sánchez, P. J., Sellart, I. M. &; Sánchez-Arévalo Lobo VJ. Tumour microenvironment and heterotypic interactions in pancreatic cancer. J Physiol Biochem 1–14 (2022) doi:10.1007/s13105-022-00875-8. PMID: 35102531
- Rodriguez Gil Y, Jimenez Sánchez, P., Muñoz Velasco, R., García Garcia , A. & Sánchez-Arévalo Lobo VJ (2021). Molecular Alterations in Pancreatic Cancer: Transfer to the Clinic. Int J Mol Sci 22, 2077. DOI:10.3390/ijms22042077. PMID: 33669845